Flexible protein source combinations for different patient needs
Digestibility and kinetics of different protein sources vary with a significant impact on Amino Acid availability1. The Protein Duo concept in Fresubin Standard Tube Feeds smartly blends casein-based proteins with whey or soy-based proteins flexibly and adapted to products intended use in different patients.
Fresubin Protein Duo: the smart protein fusion
Protein Duo concept - the smart blending for sustained Amino Acid release
Fresubin Tube Feeds provide adapted combinations and amount of fast to slow acting protein sources.
Fast acting proteins: Kick to muscle protein synthesis induced by rapid amino-acidemia in the blood stream.2
Slow acting proteins: Casein-based proteins provide a sustained slow release of amino acids into the blood stream, sometimes lasting for several hours.
Different absorption rates (appearance of plasma Amino Acids over time in minutes) of different protein sources.
Adapted from: Atherton PJ, Wilkinson DJ and Smith K. 2016 and Tang JE, Moore DR et al. 2009
Flexible protein source combinations for different patient needs
As patients are individuals,
in different conditions and different indications they may have different individual needs.
Flexible protein source combinations allow us, from a technological view point, to include high amounts of total protein, keeping the different patients’ needs in mind.
Fresubin Tube Feeds were the first to provide 50 grams of protein and 1000 kcal in 500 ml bag only.
Fresubin Tube feeds - Made with high quality proteins only
Tissue Utilization of Proteins
The effect of a Fresubin casein-based / whey-based protein blend product on muscle protein synthesis (determined via direct incorporation into muscle biopsy) in 0–4 h after feeding with and without exercises.9
Protein blends used in Fresubin Standard Tube Feeds are and will further be tested in a specifically dedicated clinical research program.
References
1. Boirie, Y., Dangin, M., Gachon, P., Vasson, M. P., Maubois, J. L., Beaufrère, B. et al. (1997). Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc. Natl. Acad. Sci. U.S.A. 1997;94(26):14930-14935.
2. Tang, J. E., Moore, D. R., Kujbida, G. W., Tarnopolsky, M. A., and Phillips, S. M. (2009). Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J. Appl. Physiol. 107, 987–992. doi: 10.1152/japplphysiol.00076.2009
3. Xu ZR et al. The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis. Br J Nutr 2015; 113(1): 25-34
Protein Sources products: Fresubin Original: sodium caseinate (from milk), soy protein; Fresubin Energy: sodium caseinate (from milk), whey protein (from milk); Fresubin 2 kcal HP calcium caseinate (from milk), whey protein (from milk)
Calculated AA profiles Fresenius Kabi standard Tube Feeds (Status November 2019), not published.
4. McGregor RA & Poppitt SD. Milk protein for improved metabolic health: a review of the evidence. Mutrition & Metabolism 2013; 10: 46-59
5. WHO/FAO/UMU. Protein and Amino Acid Requirements in Human Nutrition. Report of a Joint WHO/FAO/UNU Expert Consultation, WHO Technical Report Series, No 935 (2007)
6. Walstra et al 2006; Sarwar et al; Deutz et al 1998; WHO 2007; FAO 2013; Maubois et al 2015 . PDCAAS & DIAAS measure digestibility & quantity of EAAs provided in a diet. PDCAAS uses fecal digestibility in mice DIAAS uses ileal digestibility in pigs
7. van den Braak CC et al. A novel protein mixture containing vegetable proteins renders enteral nutrition products non-coagulating after in vitro gastric digestion. Clin Nutr (2013); 32(5): 765-71
8. Mathai JK, Yanhong L & Stein HH. Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein
9. Brook, M.S., Scaife, P., Bass, J.J., Cegielski, J., Watanabe, S., Wilkinson, D.J., Smith, K., Phillips, B.E., Atherton, P.J. (2021). A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men. https://doi.org/10.1016/j. clnu.2021.01.002